What is MALT lymph node?


Do lymph nodes have MALT?

MALT may consist of a collection of lymphoid cells, or it may include small solitary lymph nodes. Lymph nodes contain a light-staining region (germinal center) and a peripheral dark-staining region. The germinal center is key to the generation of a normal immune response. The location of MALT is key to its function.

What is MALT lymph?

Mucosa-associated lymphoid tissue (MALT) refers to collections of lymphocytes in your mucosa. It includes your tonsils at the back of your throat, as well as lymphoid tissue that may be scattered around the rest of your body, such as your gut, lungs, skin, thyroid gland and salivary (spit) glands.

What are the symptoms of MALT lymphoma?

Clinical features

Gastric MALT lymphomas may present with dyspepsia. Nonspecific symptoms include fatigue, low-grade fever, nausea, constipation, weight loss and anaemia. Recurrent respiratory tract infections. Orbital MALT lymphomas may present with blurred vision and visual field defects.

Can you live 20 years with lymphoma?

Most people with indolent non-Hodgkin lymphoma will live 20 years after diagnosis. Faster-growing cancers (aggressive lymphomas) have a worse prognosis. They fall into the overall five-year survival rate of 60%.

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What is the treatment for MALT lymphoma?

MALT lymphoma can be treated with a monoclonal antibody called Rituxan (rituximab). Rituxan targets CD20, an antigen that’s associated with gastric MALT lymphoma. (Antigens are molecules that trigger the immune response.)

What does the MALT system do for the human body?

The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated.

What is the function of MALT?

The main function of MALT is to produce and secrete IgA across mucosal surfaces in antigen specific, Th2-dependent reactions, though Th1 and cytotoxic T-cell mediated reactions can also occur, the later resulting in immunotolerance (Gormley et al., 1998; Kiyono and Fukuyama, 2004).

Is MALT lymphoma genetic?

To date, no familial background for the development of MALT lymphoma has been reported, but our cases nevertheless suggest that the combination of autoimmune disease and MALT lymphoma in a first degree relative might constitute a risk factor for consecutive MALT lymphoma development.

Is MALT lymphoma curable?

The majority of cases with MALT lymphoma are cured by eradication therapy, but there are cases that need to be treated with rituximab alone or in combination with other drugs.

Does MALT lymphoma show in blood tests?

For MALT lymphomas of the stomach, this usually involves an endoscopy. Doctors will also test for the presence of the H. pylori bacteria in the stomach. Other tests that will need to be performed include blood tests, scans of the abdomen and chest, and also a bone marrow test.

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Can MALT lymphoma spread to the brain?

From his past history, the brain tumor was suspected of being a metastatic lymphoma. Stereotactic biopsy revealed diffuse large B-cell lymhoma. Histopathological findings including lymphocytic subsets were almost identical between the primary gastric MALT lymphoma and metastatic brain lymphoma.